Infertility | How to improve fertility and reverse infertility? | New South Wales
Infertility in older women is much likely to happen but reproductive lives of mice have been extended by scientists. According to this new research, it has been found that it’s possible to boost fertility in older women or for those who have gone through chemotherapy. While it is an early days when a research team Dr Dave Listijono and Dr Lindsay Wu at University of New South Wales, and the University of Queensland’s Professor Hayden Homer said that the result which was observed on the mice is very much encouraging. This new findings were presented at the inaugural Australian Biology of Ageing Conference, hosted by the University of New South Wales. Dr Dave Listijono said that it was almost impossible to get pregnant for mice after completion of their 12 to 13 months but according to this new study, mice still got pregnant at 16 to 17 months which is equivalent of the late 40s in human age.
Reproduction clock of a woman starts tickling down after completing the age of 30, said Professor Homer. Anyway, according to this new study, it has been assured that there’s a possibility that even when the effects of ageing have already set in, you could potentially reverse some of that like fertility issues. This study is not a miracle that will help those women who are 60 year old and who are menopausal pregnant but this study is just like miracle for those growing number of women who find that they’re ready in life to start a family, but biologically they might have missed the mark slightly. Dr Listijono said mice’s biological process is just like human being and if it is effective for mice then it’s very promising for human being too. In the coming days, we will potentially use a simple pill in order to improve oocyte (egg) quality and fertility too. For the study purpose, the family of protein that is called as sirtuins were involved. One sirtuin regulates a particular protein, the levels of eggs which were dropped in from older women. The old aged mice and those mice that were given chemotherapy were fed the precursor to a chemical which activates sirtuin naturally.
Fertility expert, Professor Homer said that when we did that in old aged mice, we found that now we can improve the quality of fertility in older mice and some of the preliminary findings suggest that we can actually reverse what is quite severe infertility. Experts said that with the help of this treatment, it seemed to protect eggs during chemotherapy, which can leave cancer survivors unable to have children for whole life. Dr Listijono at University of New South Wales said that chemotherapy is a procedure which leads to infertility through irreversible damage to the oocyte for life time. The preliminary research suggests that it is a miraculous ability to reverse infertility which occurred due to chemotherapy. Professor Homer said that this is a subject to funding the researchers in hope to move on to clinical trials “within a few years”.
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