Infertility | how receptor of sperm could end the male infertility? | Berkeley
Infertility is a leading illness in millions of people in the world. According to a new study, it has been found that male infertility can be end after landmark Berkeley study that shows how sperm are given a “power boost” to reach the egg. According to scientists, it has been discovered that is a crucial mechanism which can cause reproduction and can lead to the development of new fertility treatments. New findings suggest that it could lead to the development of a unisex contraceptive pill, or pave the way for new fertility treatments. The protein receptor sits on the tail of sperms and it respond to the progesterone (sex hormones of female) which is releases by the eggs. When sperms come closer to the eggs, the progesterone activates the receptor of the sperms like causing the tail to snap like a whip, gives power to the sperms into through the cells protecting the egg.
Infertility occurs, when the receptor doesn’t respond to the female sex hormones. Scientists says that this discovery is about how the switch behaves could lead to the creation of a drug that can disable the receptor and which could be used as a unisex contraceptive. It also raises the prospects of new fertility treatments, in order to reactivate the protein receptor in those cases where it is failing. It has been found that one couple out of seven is found to be unable to get pregnant naturally and approximately half cases is linked to male infertility that is linked with sperm problems. Dr Melissa Miller, a postdoctoral fellow at the University of California, Berkeley and San Francisco said that people take the fertilization as the marathon where the most powerful sperm is going to win but we think it is like the Tour de France, where the riders in front are blocking the wind for the actual winner.
However, fertilization is a sport that is played by team and the first sperm clear the way expending their energy through the barrier cells so that the slow and steady sperm can get into the oocyte. According to scientists, making a unisex contraceptive was really a cool target. If progesterone can be stop from inducing a power stroke then sperms are not going to be able to reach or penetrate the oocyte. Although, there are some other possible target of this unisex contraceptive is to prevent the power kick, which is known as hyper action, and it could be one of the better option for unisex argued by team. For yet, health experts are unable to determine the cause of male infertility by nearly 80 per cent. Sperm plays the Vitol role in half of all cases of infertile couples.
Just five years ago, it was very difficult to study with ordinary techniques of lab about the inner functions of the sperm which is the smallest cell of the body. But now all thanks goes to new techniques which helps the scientists at the University of California, Berkeley to study about stick electrodes on a sperm’s tail and record its reactions to hormones. These developed techniques led the discovery that a large receptor on sperm tails that is a calcium channel dubbed CatSper can be activated by progesterone from the egg. According to some biologists progesterone cannot act directly on the calcium channel, but on some other receptor that, in turn, activated the calcium channel. It is the proof of the case and they showed that progesterone actually binds to a previously mysterious enzyme called ABHD2, which is found at high levels in sperm. Once it binds to the enzyme, which is found on the surface of the sperm, it removes a lipid that has been inhibiting the calcium channel. After releasing of inhibition, CatSper opens the gate to calcium ions and eventual sperm activation. Ms Miller said that the inhibitor of the calcium channel CatSper is probably available there to prevent the sperm from prematurely sprinting toward the egg and using up their limited supply of energy.